Formål
To understand the basic mechanism of chemicals inducing adverse health effects in man, and how to integrate this information into methods to determine the risk associate with exposure to chemicals. The key objective is to understand to live safely in a chemical world. This course is part of the subject package ‘Human Biology’ for students at the master level.
Indhold
Introduction to the general principle of toxicology, toxico-kinetics with the focus on susceptible populations. Another focus area is risk assessments – hazard identification, exposure assessment and risk characterisation. Methods for hazard identification, environmental epidemiology and experimental systems will be introduced. The role of chemicals in the development of major human diseases or health problems will be presented, cancer, reproduction, allergy and asthma with a strong emphasis on gene-environment interaction. Case studies on actual risk assessment cases will be discussed.
Undervisningsformer
Mainly lectures and some colloquia. 4-5 hours/week in 7 weeks.
Underviser
- Responsible teacher: Herman Autrup.
- Other teachers: Torben Sigsgaard, Ole Find Petersen, Eva Bonefeld Jørgensen, Lars Mølhave.
Undervisningsmaterialer/lærebøger
- Klaassen CD and Watkins III. Casarett & Doull´s Essentials of Toxicology. McGraw-Hill New York, ISBN 0-07-138914-8.
- Supplementary material: Orginal papers and reviews, copies of overheads.
Evalueringsform
- 2-hour written examination with all usual aids.
- evaluation according to the Danish grading scale (the 7-point scale).
- internal examiner.
Omfang
5 ECTS.
Sprog
- Material: English.
- Spoken language: English.
Undervisningsperiode
2nd quarter.
Eksamensterminer
- Eksamen: 2. kvarter.
- Reeksamen: Efter aftale med faglærer.
Kursustype
Overbygningskursus.
Udbyder
- Institut for Miljø- og Arbejdsmedicin.
- Indgår i følgende fagpakker: Humanbiologi – Kandidatfagpakke.
Læringsmål
Når kurset er færdigt forventes den studerende at kunne:
- Beskrive kemiske stoffers skæbne i organismen, optagelse, fordeling, omdannelse og udskillelse.
- Beskrive hvorledes kemiske stoffer kan påvirke organismen, herunder redegør for den toksiske mekanisme på molekylærbiologisk niveau.
- Redegør for mulige kroniske effekter af kemiske stoffer og analysere hvilke faktorer der kunne påvirke udviklingen af disse effekter.
- Forklare hvorledes miljøfaktorer, fx luftforurening, påvirker vores sundhedstilstand.
- Beskrive genetiske, fysiologiske og sociale forhold som baggrund for forskellig følsomhed over for kemiske stoffer.
- Anvende generelle principper for risikovurdering, farlighed, eksponering og risikokarakterisering på simple situationer.
