Sequence Analysis, Structure Prediction, Biological Function
- 12 point PhD course, two week intensive course from May 19 to 30, 2008.
- A two week Ph.D. course will be held again from May 19 to 30, 2008 covering biological macromolecules from sequence analysis through 3D-structure to the understanding of biological function at the molecular level. The course also involves aspects of systems biology, analysis of protein-protein interaction data and data from transcriptomics experiments.
- The course is offered in an onsite version as well as an internet transmitted version. The internet version of the course will be a combination of live, real-time transmitted lectures and webbased exercises, where the students will be introduced to a range of computational methods used in the field and to internet biocomputing services available. It will be possible to communicate and ask questions during the lectures and exercises via chat lines maintained by CBS staff.
- To apply for the course, please sign up through the online application form. The application deadline is February 29, 2008.
- The course will be relevant for Ph.D. students within biochemistry, physics, chemistry or molecular biology with an interest in DNA, RNA and/or proteins.
The following topics will be covered
- Nucleotide and amino acid sequences: advanced multiple alignment methods, sequencing, database overview, gene finding, phylogeny reconstruction.
- Protein, RNA and DNA structure: prediction tools, artificial neural networks, genetic algorithms, hidden Markov models, threading, structural alignment, homology modelling, protein surface and secondary structure prediction, DNA bending, RNA secondary structure.
- DNA microarrays: Analysis of DNA microarray data including normalization, significance, clustering, principal component analysis, reverse engineering of regulatory networks and promoter analysis.
- Protein and gene function: protein dynamics, catalytic mechanisms, binding sites and binding energies, docking, energy minimization, structure based drug design, gene function prediction.
Course Structure
- The course will consist of lectures and computer exercises, where the students will be introduced to a range of computational methods used in the field and to Internet biocomputing services available. It is arranged by Center for Biological Sequence Analysis at BioCentrum-DTU.
- For more information, contact Anders Gorm Pedersen or Dorthe Kjærsgaard.
